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Find the answers to the most frequently asked
questions you might have about JC Discovery® models and services.
What's the timeline for model generation?
The estimated timeline depends on the desired genetic modification, careful evaluation of the target gene locus and technology used, CRISPR-Cas9 or homologous recombination. From project initiation to F1 generation and genetic validation, it takes between 16 and 44 weeks. We take care of securing your strain before ensuring the customized breeding providing you with strandardized cohorts and supporting your research projects within the competitive timeframe.
Can I make a model with complex multitask alleles?
Our team of mouse geneticists has a longstanding experience and will guide you to carefully evaluate the feasibility of the desired gene editing to achieve complex multitask alleles.
What is the technical and economical feasibility for the creation of my model?
A dedicated team of mouse geneticists experts will work with you to design a model that will technically achieve your research needs and economical options. They use wide variety of model generation technologies and can advise on which strategies will minimize risk. It will take 2 weeks in average depending on the complexity of the model to be designed.
Which type of phenotypic analyzes are used to characterize my model?
The model characterization is driven with an unmet platform including a wide suit of flow cytometers and mass spectrometers to lead robust cytomics and proteomics projects. We are offering more than 200 quantitative parameters allowing deep immunophenotyping.
How many samples can you process at the same time in a standardized manner?
At JC Discovery®, we can process 48 samples at the same time, i.e. up to 8 experimental groups consisting of 6 mice. We offer comparative analysis in normal and pathological conditions (tumor, inflammation, infection, auto-immunity) with efficacy therapeutic dose analysis.
What types of experimentation can you perform on the characterized models?
Our field of expertise includes immunology, immuno-oncology (various tumour indications and types), inflammation (skin, intestine, peritoneum, etc.), autoimmune and infectious diseases. We offer extensive experimental disease preclinical models which are functionally fully characterized. They are valuable resources for testing novel drug candidates and their mechanism of action. At JC Discovery®, we build a customized program to reach your research objectives.
What are the objectives of Fast-Track® T-Cells?
Fast-Track® T-Cells offers precision R&D preclinical programs to accelerate the selection of lead T-Cell products and models:
- Gene editing and engineering of therapeutic T-Cells
- In vivo preclinical evaluation of anti-cancer adoptive T-Cell therapy including CART-T cells
- Mode of action of therapeutic compounds using advanced interactomics
- Enhanced CART-T cells with improved effector functions and durability
How can I follow up my customized breeding projects ?
All stages of your animals’ breeding are supported by a unique and dedicated project manager to assure the strict respect of your needs and requirements. With Anibio, your dedicated customized breeding software, you can access 24/24 7/7 your project details to follow up the development programs.
A nique and dedicated project manager (with a PhD in molecular biology/genetics) will guide you from the beginning to the end of the project.
What is the timeframe to generate experimental cohorts of newly created models?
It usually takes several weeks from the time a request is received until the experimental cohorts are available for being used. Assuming a minimum of 2 weeks for ordering, 3 weeks for gestation, 3 weeks of weaning, 3 weeks post-weaning and 2 weeks for health testing post-weaning, it is usually a minimum of 12-13 weeks from request receipt to transfer the cohorts to you. This can be lengthened by factors such as the size of cohorts, the sex and age of animals breeding strategy.
What will be the health status of the cohorts of genetically edited rodent models?
The production of specific and complex research models, such as genetically altered mouse or rat models requires a high skill level in different scientific areas as well as advanced technological platforms.
Newly designed rodents in customized breeding are bred according to our quality criteria and whilst respecting our ethics policy, with a guaranteed SOPF or SPF health status.
Who does take care of the customs formalities of the destination country?
Our team of commercial assistants manage with you all the regulatory aspects for shipping your models outside France.
What are the conditions to transport genetically edited models?
We have established an exclusive and strict transport policy to limit stress and respect the highest commitments of animals’ welfare during travel. All our delivery drivers are trained in biosecurity and animal welfare standards.
Motorways are systematically used to reduce jolting and journey times for the animals.
Our teams of drivers are based in different areas in Europe in order to ensure that our rodents’ journeys take place in one go without stopping throughout Europe. This policy enables us to reduce the animals’ transport time.
Which packaging will be used to transport my model safely?
Innovative transport packaging has been designed and created to unable the transport of newly designed models with the highest commitments of welfare.
We ensure health status of the models by using a perfect isolation of the crate with performant air filtration system. The hermetic crates do not include neither staple nor metallic element present to invoid injuries. They contain sterile and hydrating transport gel, together with bedding and enrichment inside the crate. Our innovative crates are 100% recyclable packaging designed to be reused.
What are JC Discovery® services?
JC Discovery® develops highly predictive in vitro and in vivo models of human diseases to increase the clinical translatability. It helps leading biopharmaceutical companies and academic research institutions to validate and develop novel therapeutic candidates acting on immune system in the field of immuno-oncology, inflammation, auto-immune, and infectious diseases. At JC Discovery®, we provide encompassing genetic engineering models and preclinical services to make drug discovery phase a strategic time frame to decide the future of your drug, at the early phase of development.
What are the advantages to work with JC Discovery®?
Long-lasting expertise, state-of-the-art infrastructure, and robust data mining, JC Discovery® gives access to key stage services enabling drug target validation, compound validation and clinical trial optimization. Understanding core pathways within immune system to comprehensively study disease mechanisms are also translational preclinical services that we are offering.
Why does JC Discovery® offer these high value services?
Drug discovery and development is a long, complex, costly, and high-risk process that takes over 10–15 years with an average cost of over $1–2 billion for each new drug to be approved for clinical use. Advance a therapeutic candidate to phase I clinical trial is very challenging. JC Discovery® has developped the Fast-TrackTM solutions to help you take the decision at the discovery stage and give your drug candidate the best chance to enter and succeed in the preclinical and clinical phases.
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